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Dan Bricklin has a lengthy but worthwhile piece on the challenges facing the startup developer these days that puts some meat behind Zuckerberg's concern of a few months ago that building a consumer facing web service today has become a lot harder due to the challenges of supporting the myriad of endpoint devices.
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Where I think the lean startup math gets screwed up: http://goo.gl/6v9d9 (has to do with mobile device proliferation)

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